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Title   근치적 위절제술을 시행받은 위암 환자에서 상황(메시마-엑스)의 항종양 효과 ( The Effects of Mesima-Ex, the Immunomodulator in Curatively Resected Gastric Cancer )
Publicationinfo   1997 Jan; 029(05): 800-807.
Key_word   Mesima-Ex, Immunomodulator, Phellinus linteus, Gastric cancer
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Abstract   Purpose: The Mesima-Ex is a kind of biologic response modifier, which is extracted from a mushroom called Phellinus linteus. Mesima-Ex consists of various chemical compounds which include protein bound polysaccharide, mucoprotein, triterpenoid, and quinones. Mesima-Ex exerts its antitumor effects by augmenting host immune response without any toxic side effects. In vitro study, Mesima-Ex seems to potentiates antibody dependent cell mediated cytotoxicity(ADCC) and cell mediated cytotoxicity(CMI) against tumor cells. We initiated this study to verify antitumor effects of Mesima-Ex as an antineoplastic agent. Materials and Method: Gastric cancer patients who underwent curative resection with normal hepatic and renal function were eligible. They were divided into two groups by random number table. One group(N=30: Mesima-Ex group) received postoperative adjuvant chemotherapy with 5-FU(500 mg/m2 weekly), adriamycin(40 mg/m2 every 3 weeks) and Mesima-Ex(6 cap daily per Os). Another group(N=37: control group) received 5-FU and adriamycin only without Mesima-Ex. NK(natural killer cell) activity, ADCC(antibody de- pendent cell mediated cytotoxicity), CD4+, and CD8+ cells were measured and an analysis of disease free survival rate of the two study groups was performed. Results: Sixty seven patients were enrolled in this study. Their median age was 55 years old. NK activity(basal activity: 25%) was enhanced significantly at the 2nd, and 4th months in the Mesima-Ex group(28.9%, 43.4%, p<0.05). ADCC was also enhanced from 37% to 42.1% at the 2nd month in the Mesima-Ex group(p<0.05). The control group did not show any significant change in NK activity or ADCC. The CD4+ cell ratio was increased (continue.....)
저 자   조세행(Se Haeng Cho),김주항(Joo Hang Kim),박병규(Byung Kyu Park),박수진(Soo Jin Park),안상훈(Sang Hun Alhn),정현철(Hyun Chul Jung),노재경(Jae Kyung Rbo),김병수(Bybung Soo Kim),노성훈(Sung Hun Robo)